CD64、CRP、IL-6在儿科感染性疾病中的诊断价值分析

Analysis of diagnosis value of CD64,CRP,IL-6 in pediatric infectious diseases

目的探讨中性粒细胞表面标志物CD64、CRP、IL-6在儿科感染性疾病中的应用价值。方法将2007年10月～2011年10月儿科病房(包括NICU住院)住院患儿116例,分为重症感染组(49例);一般感染组(36例);非感染组(31例)。3组进行CD64、CRP、IL-6水平测定和比较。结果重症感染组CD64为(6262.24±3776.43)分子数/细胞,感染组为(3727.24±1276.32)分子数/细胞,非感染组为(2176.19±946.32)分子数/细胞,重症感染组CD64水平明显高于其他两组,3组间CD64值差异有极显著意义(P<0.01)。CD64诊断感染的最佳临界值为2587分子数/细胞,其诊断重症感染的敏感度为89.21%,特异度为78.35%;对所有感染的诊断敏感度为67.51%,特异度为82.45%。结论细菌感染时CD64水平明显升高,全身性细菌感染时升高尤为明显,与CRP、IL-6相比诊断优越性更明显,特别对重症感染患儿诊断更有价值,可以作为早期诊断儿科感染性疾病的实验室依据。

Objective To investigate the application of the neutrophil cell surface markers CD64,CRP,IL-6 in pediatric infectious diseases. Methods From October 2007 to October 2011 pediatric wards （including NICU hospitalization） 116 cases were divided into severe infection（49 cases）,general infection（ 36 cases）,non-infectious（31 cases）. CD64,CRP,IL-6 levels in 3 groups were measured and compared. Results CD64 as a result of severe infection group （6262.24±3776.43） molecules / cell,infection group （3727.24±1276.32） molecules/cell,non-infected group （2176.19±946.32） molecules/cell,levels of CD64 in severe infection group was significantly higher than the other two groups,CD64 value was significant difference in three groups （P0.01）. The best critical value of CD64 was 2587 molecules/cell,the diagnostic sensitivity of severe infection with 89.21% and a specificity of 78.35%; diagnostic sensitivity of 67.51% for all infections,a specificity of 82.45%. Conclusion CD64 levels are significantly increased during bacterial infection,particularly during systemic bacterial infection,and comparing to CRP,IL-6,the diagnostic superiority is more obvious,especially for children with severe infection,it can be as laboratory evidence of early diagnosis for pediatric infectious diseases.