SnCl_4·5H_2O高效催化-锅法合成1-乙酰胺基苯甲基-2-萘酚

One-pot Synthesis of N-[Phenyl-(2-hydroxy-napthalen-l-yl)-methyl]-acetamide Catalyzed by SnCl_4·5H_2O

采用SnCl_4·5H_2O为催化剂催化2-萘酚、苯甲醛和乙酰胺的三组分一锅法类Ritter反应合成了1-乙酰胺基苯甲基-2-萘酚(AAN)。考察了原料配比、催化剂用量、反应温度和反应时间等因素对AAN收率的影响.确定了适宜反应条件为:n(2-萘酚):n(苯甲醛):n(乙酰胺)=1:1.4:1,催化剂用量为反应物总质量的6%、85℃反应35min,AAN的收率可达96.2%。该合成工艺路线简捷,催化剂价廉易得,催化活性高,使用方便,反应条件温和,收率可观。

An efficient and direct procedure has been developed for the preparation ot N-Lphenyl-~z- hydroxy-napthalen-l-yl）-methyl-]-acetamide （AAN） by a one-pot, three, component and Ritter-analog reaction of 2-naphthol, benzaldehyde and acetamide in the presence of SnCl4·5H2O as catalysts. The Ritter- analog reaction was carried Out with n（2-naphthol） ： n（benzaldehyde） ： n（acetamide）= 1 ： 1.4： 1,and re,ass fraction of catalyst in all of reactants 6%. The reaction was run at 85℃ for 35 min. The yield of AAN was 96.2%.SnCl4·5H2O showed excellent catalytic activity for the reaction. The mild reaction conditions offer several advantages such as inexpensive, high yield and easy work-up. The catalyst makes the procedure an attractive alternative to the existing methods for the synthesis of the product.