脑涨落图仪检测抑郁症患者脑内神经递质功率变化特点分析

Analysis of variation of intracerebral neurotransmitter power detected by using EFG in patients with depression

目的利用脑涨落图仪检测分析抑郁症患者脑内神经递质功率变化的特点,探讨其对抑郁症的临床指导意义。方法选取抑郁症患者组和正常对照组各40例,均给予汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、症状自评量表(SCL-90)评定,并采用脑涨落图仪检测,所测量数据资料进行t检验等统计处理,对比分析两组脑内神经递质功率变化情况。结果患者组HAMD、HAMA、SCL-90量表评定均值显著高于对照组(P<0.01)。患者组脑内9种神经递质的实测功率值都低于正常对照组(P<0.01);患者组的相对功率检测值中去甲肾上腺素(NE)低于正常对照组(P<0.05),其余神经递质与正常对照组比较差异无显著性意义;患者组总功率低于正常对照组(P<0.01);患者组血管舒缩指数低于正常对照组(P<0.05);两组之间的兴奋抑制指数、运动指数、熵值差异无显著性意义。结论抑郁症与脑内神经递质失调有关,脑涨落图仪对抑郁症的临床诊断、治疗用药、疗效判定方面有一定的指导作用。

Objective Using encephalo fluctuation graph （EFG） to detect the variation characteristics of brain neurotransmitter power in depressive patients and to explore the value of EFG in the diagnosis and treatment of depression. Methods 40 depressive patients （ study group） and 40 healthy controls （ control group） recruited randomly were assessed with Hamilton depression scale （HAMD）, Hamilton anxiety scale （HAMA）, symptom checklist 90 （SCL- 90） and then detected by using EFG. The data was analyzed by using t-test and etc to explore the difference of neurotransmitter power variation between the two groups. Results Scores of HAMD, HAMA and SCL-90 in study group were significantly higher than those in control group （P 〈 0.01 ）. Actual measured power of 9 neurotransmitters in study group were significantly lower than those in control group （ P 〈 0.01 ）. The relative power of noradrenaline in study group was significantly lower than that in control group （P 〈 0. 05 ） , and there were no significant differences of other neurotransmitters between the two groups. The total power and index of vasomotion in study group were significantly lower than those in control group （P 〈 0.05,0.01 respectively）. There were no significant differences in excitement inhibition index, movement index and entropy between the two groups. Conclusion Disturbance of intracerebral neurotransmitter plays a role in the etiology of depression. EFG may have guiding role for the diagnosis, treatment and outcome evaluating of depression.