胃食管反流病患者食管、胃运动功能的研究

Study on gastroesophageal motility in patients with gastroesophageal reflux disease

目的观察胃食管反流病(gastroesophageal reflux disease,GERD)患者食管下括约肌功能及胃底容受性舒张、胃窦排空功能,为临床治疗GERD提供理论依据。方法 31例GERD患者和10例志愿者通过灌注式测压导管监测GERD患者食管括约肌压(LESP)和一过性食管下括约肌松弛(TLESR),并实时B型超声监测胃近端容积和胃窦截面面积来反映胃底容受性舒张及胃排空情况,来观察GERD患者的食管、胃运动功能。结果 GERD患者LESP降低,TLESR频次增加(P<0.05);试餐时胃近端容积减小(P<0.05);胃排空时间延长、速率降低(P<0.05)。结论胃食管反流病患者可能存在着食管下括约肌运动障碍和胃运动障碍。

Objective To explore the changes of gastroesophageal motility in patients with gastroesophageal reflux disease for providing a basis for the clinical treatment.Methods The lower esophageal sphincter pressure（LESP） and transient lower esophageal sphincter relaxation（TLESR） were determined by perfusion manometry catheter in 31 patients with GERD and 10 healthy volunteers.Proximal gastric volume and antral cross-sectional area were monitored through real-time B-mode ultrasound to observe the gastric receptive relaxation and gastric emptying.Results Compared with controls,LESP decreased and TLESR increased in patients with GERD（P0.05）,proximal gastric volume decreased（P0.05）,and gastric emptying was extended and the speed was decreased in patients with GERD（P0.05）.Conclusion The patients with gastroesophageal reflux disease may have lower esophageal sphincter motility disorders and gastric motility disorders.