输精管结扎与实验性高血脂对听觉脑干电位及血清过氧化脂质的影响

Influence of vasectomy and experimental hyperlipemia on brain stem response and serous lipid peroxides

输精管结扎12月以上日本大耳白兔16只,随机分为输精管结扎基础饲料(V-S)组和输精管结扎胆固醇(V-Ch)组。体重相近的同种雄兔16只,分为对照基础饲料(C-S)和对照胆固醇(C-Ch)组。听觉脑干电位检测结果表明:气导ABR阈值,输精管结扎组(V-S.V-Ch)与各门对照组比较无差异(P<0.05),而高胆固醇饲料组(C-Ch.V-Ch)则显著地高于对照组(P<0.01),并且与TC水平正相关(P<0.01);各组Ⅰ、Ⅲ、Ⅴ波潜伏期无延长,波间期各组比较也无显著差异,(P>0.05)。血清过氧化脂质含量与TC水平正相关(P<0.01)而与血清抗精子抗体滴度无相关(P>0.05)。本实验证明,实验性高血脂使气导ABR阈值及血清过氧化脂质增高,而输精管结扎对其无影响。

Sixteen rabbits vaseetomized 12 months were divided into vasectomy stock diet(V-S) group and vasectomy cholesterol diet(V-Ch)group. 16 male rabbits of same body weight were divided into control stock diet(C-S) group and control cholesterol diet (C-Ch) group. The results showe that (1)the ABR threshold values of the vasectomy groups (V-S,V-Ch) were not different from those of the control groups(C-S,C-Ch), but the ABR threshold values of cholesterol diet groups(V-Ch,C-Ch) were markedly higher than those of stock diet groups (V-S,C-S) and were positively related to the TC level (P<0.01); (2) the Ⅰ, Ⅲ, Ⅴ latent periods and Ⅰ-Ⅲ, Ⅲ-Ⅴ intervals of brain stem response ahd no significant changes in all groups (P>0.05); (3) the serous lipid peroxide levels had apparently positive relation with the serous total cholesterol level (P<O.01), but no significant relation with antibody titres against sperm antigens (P>0.05).