局灶性脑缺血大鼠海马Nogo-A受体的动态表达

Dynandc expression of Nogo-A receptor in the following focal cerebral ischenmia in rats

的探讨局灶性脑缺血大鼠海马Nogo-A受体（Nogo—recepter，NgR）的动态表达。方法电凝右侧大脑中动脉建立大鼠局灶性脑缺血模型，免疫组织化学染色检测脑缺血后不同时间点缺血侧海马CA1、CA2和CA3区NgR表达。结果缺血侧海马CA1和CA2区在脑缺血后第1天NgR表达上调，CA3区在第2天表达上调；第5天CA1、CA2和CA3区NgR表达均降至最低；第28天CA1、CA2和CA3区NgR表达再次上调。结论缺血侧海马NgR表达在不同区域呈现不同的变化特点，但总体变化趋势呈现出“两峰一谷”的现象，提示NgR在脑缺血后不同时期可能具备不同的功能。

Objective To investigate the dynamic expression of Nogo-A receptor （NgR） in the hippocampus following focal cerebral ischemia in rats. Methods The focal cerebral isehemia model was established by electrocoagulating the right middle cerebral artery in rats. The expression of NgR in the ischemic hippocampal CA1, CA2 and CA3 regions at different time points after cerebral isehernia were detected by inmaunohistoehemical staining. Results The expressions of NgR were up-regulated in hippoeampal CA1 and CA2 regions at the first day, in the CA3 region at the second day after cerebral isehemia; the expressions of NgR in the CA1 and CA2 regions at the fifth day was decreased to the lowest. The expressions of NgR was up-regulated again in the CA1 and CA2 regions at the 28th day. Conclusions The NgR expression in the hippocampus in isehemie side showed different change characteristics at different regions, however, the overall change trend showed a ＂2 peaks and a valley＂ phenomenon, which indicated that NgR might have different functions at different time periods after cerebral isehemia.