迷走神经刺激对家兔高血钾时心室肌单相动作电位及心室肌细胞跨膜电位的影响

Effects of vagal stimulation on monophasic action potentials and transmcmbrane potentials of hyperkalcmic rabbit heart

本文观察了电刺激迷走神经对家兔商血钾时心室肌单相动作电位(MAP)及单个心室肌细胞跨膜电位(TMP)的影响。结果表明,迷走神经刺激可以改善高血钾引起的心室内传导阻滞,使单相动作电位振幅(MAPA)、单相动作电位0相最大上升速率(MVmax)增加,单相动作电位时程(MAPD)延长,亦使单个心室肌细胞静息电位(RP)、动作电位振幅(APA)和0相最大上升速率(Vmax)增加,动作电位时程(APD)延长。另外,两种记录方法在同一部位的MAPD与APD完全一致。

Effects of vagal stimulation on monophasic action potentials (MAP) and transmembrane potentials (TMP) of hyperkalemic rabbit heart were investigated. The results showed that ventricular conduction block induced by hyperkalemia can be improved by vagal stimulation. Amplitude of MAP (MAPA) and maximum rate of rise of MAP (MVmax) were increased, durations of MAP(MAPD) lengthened. Also in single ventricular cell amplitude of action potential (APA) and maximum rate of rise of action potential (Vmax) were increased, while durations of action potential (APD) lengthened. In addition, MAPD and APD measured at the same site are completely in accordance.