根除幽门螺杆菌治疗对反流性食管炎治疗的影响（附289例报告）

目的：探讨根除幽门螺杆菌对反流性食管炎疗效影响。方法：选择2008年7月-2010年3月在我院门诊及住院部已确诊的289例RE患者，证实Hp感染，既往未行抗Hp治疗，HP阳性组随机分成两组：一组给予埃索美拉唑镁20mgBid（阳性治疗组）；一组给予埃索美拉唑镁20ragBid＋根除HP治疗，对于Hp阴性组给予埃索美拉唑镁20mgBid（阴性治疗组），总的疗程为8周，8周后所有病人均复查胃镜及HP检测。结果HP阴性组是206例，HP阳性组是83例（对照组30例，根除HP治疗组53例）；根除治疗组中，其中8例未成功根除，HP根除率为96％，总的愈合率为80．27％，其中HP阳性对照组、HP阳性成功根除治疗组、HP阳性未成功根除治疗组、阴性对照组愈合率分别为76．7％、77．78％、和75％、81．55％，各组参数间差异均无统计学意义fP〉O．05）。结论：我们的临床试验证明是否根除Hp治疗对反流性食管炎的愈合均不产生显著影响。

To investigate the eradication of Helicobacter pylori on reflux esophagitis curative effect. Methods： 2008 July - 2010 March in our hospital outpatient and inpatient department has been diagnosed in 289 patients with RE, both positive confirmed Hp infec- tion, previous without treatment against lip, in HP positive group was randomly divided into two groups： one group of esomeprazole mag- nesium 20rag Bid （ positive treatment group）; a group give esomeprazole magnesium 20mg Bid ＋ HP eradication therapy, for Hp negative group given esomeprazole magnesium 20mg Bid （ positive treatment groui~）, the total duration of treatment was 8 weeks, 8 weeks after all patients were reexamined with gastroscopy and HP detection. Results HP negative group is 206 cases, HP positive group was 83 cases （ 30 cases in the control group, HP eradication therapy group 53 cases ）; eradication therapy group, including 8 cases of failed eradication, HP eradication rate was 9.6%, the total effective rate is 80.27%, where HP positive control group, HP positive success of eradication therapy group, HP positive failed eradication therapy group, negative control group healing rates were 76.7%, 77.78%, and 75%, 81.55% groups of parameters, there were no significant differences （ P 〉 0.05 ）. Conclusion： our clinical trials prove whether Hp eradication therapy for re- flux esophagitis healing has no remarkable influence.