内、外源性性激素对大鼠实验性十二指肠溃疡形成的影响

Effects of endogenous and exogenous sex hormones on experimental duodenal ulceration in the rat

雌鼠较雄鼠有较强的抗实验性十二指肠溃疡(DU)形成的能力,卵巢摘除后这种能力减弱,睾丸摘除对DU形成无影响。戊酸雌二醇和孕酮也有抗雄鼠DU形成的作用,而丙酸睾丸酮则无此作用。雌鼠血清胃泌素水平和胃酸分泌均低于雄鼠,卵巢摘除后血清胃泌素水平和胃酸分泌均明显升高。皋丸摘除对雄鼠血清胃泌素水平和胃酸分泌无影响。戊酸雌二醇可减少雄鼠血清胃泌素水平和胃酸分泌,而丙酸睾丸酮则无此作用。本实验结果可部分解释女性DU发病率明显低于男性的临床现象。抑制胃泌素和胃酸分泌作用,可能是雌二醇抗DU形成的机制之一。

In the female rats, it was found that the antiulcer ability was stronger than in male rats, and significantly decreased after ovariectomy. Castration of male rats had no significant effect on ulceration. Treatment of male rats with estradiol 17-β-valerate and progesterone respectively was found to have significant antiulcer activity, but the testosterone propionate had no such effect. The serum gastrin level and gastric acid secretion were lower in female rats than in male rats. After ovariectomy, serum gastrin level and gastric acid secretion both significantly increased up to male level. Gastration of male rats had no significant effects on both gastrin level and gastric acid secretion. Estradiol could significantly decrease gastrin level and gastric acid secretion in male rats, but testosterone and progesterone both had no significant effects on either parameter. These findings can partly explain the clinical phenomenon that males have a higher propensity to develop duodenal ulcer than females. The mechanism of antiulcer activity could be explained by inhibition on gastrln and gastric acid secretion by estradiol, the antiulcer activity of progesterone may be related to some other factors.