巴曲酶治疗急性缺血性脑血管病的临床观察

Observation of Batroxobin in the treatment of acute ischemic cerebrovascular disease

目的:评价巴曲酶治疗急性缺血性脑血管病的疗效。方法:将141例随机分为2组:治疗组70例,在12小时内给予巴曲酶,10Bu加生理盐水250ml静脉点滴1小时左右,第3天和第5天均用5Bu,同时使用常规治疗药物。治疗观察期间不给予中医或物理治疗。对照组71例,仅给予常规药物治疗。两组均于治疗后的第1、3、5、14天分别评价疗效。结果:治疗组70例,基本痊愈8例,显著进步20例,进步30例,有效例数总计58例,总有效率为82.85％;对照组71例,基本痊愈3例,显著进步14例,进步30例,有效例数总计47例,总有效率为64.78％。两组相比有显著差异(P<0.05)结论:巴曲酶是一种作用快、疗效好、安全性高的治疗急性缺血性脑血管病的药物,在溶栓治疗中值得应用。

OBJECTIVE: To evaluate the effect of Batroxobin in the treatment of acute cerebrovascular disease. METHOD: 141 patients with acute cerebrovascular disease were randomly divided into two groups. Within 12 hours,70 cases of the treated group received 10 Bu of Batroxobin with 250 ml of normal saline by means of intravenous drip which lasted for about one hour, and on the 3th and 5th day. 5 Bu of Batroxobin was used respectively with drugs of usual treatment. In the period of clinical observation,treatment of traditional Chinese medicine and physiotherapy should be avoided. 71 cases of the control group reived drugs of usual treatment. Evaluation of clinical effect for the two groups was respectively conducted on the first, 3th, 5th and 14th day after the treatment. RESULT:Of the 70 cases in the treated group,8 cases were as good as cured, 20 cases were significantly improved, 30 cases were improved. 58 cases were curative,the curative rate being 82. 85 %. Of the 71 cases in the control group,3 cases were as good as cured, 14 cases were sighificantly improved, 30 cases were improved. 47 cases were curative,the curative rate being 64. 78%. There was a significant difference between the two groups(P<0. 05). CONCLUTION :Batroxobin is characterized by remarkable effect and safety in the treatment of acute cerebrovascular disease,and can be used in thrombolytic therapy.