皮肤扩张术机理探讨

Exploration of the mechanism of skin expansion

目的 探讨皮肤扩张术 (Skinexpansiontechnique,SET)的机理。方法 以家犬为动物模型 ,应用显微分光光度计及放射微球技术 ,对扩张后皮肤表皮有丝分裂及皮瓣微循环进行了测定。结果 ①被扩皮肤表皮明显增厚 (P <0 0 5 ) ;②基底细胞有丝分裂较对照组显著增强 (P <0 0 1) ;③皮瓣微循环较即刻皮瓣显著增强 (P <0 0 1)。结论 ①SET并非仅以代偿为基础 ,而是复制了新的“剩余”皮肤 ;②增强了皮瓣微循环 ,增大皮瓣存活面积。并就快速扩张时限及即时扩张机理进行了讨论。

Objective In order to explore the mechanism of skin expansion technique (SET). Methods Domestic dogs were used in this experiment.The epidermal mitotic activity,capillary blood flow change of the expanded flap were observed with microspectrophotometer and radioactive microsphere technique.Results ①The epidermis of expanded skin was significantly thicker than that of other groups ( P <0 05). ②The epidermal mitotic activity was elevated significantly( P <0 01). ③The capillary blood flow of expanded flaps increased significantly ( P <0 01). Conclusions ①The surplus skin produced by SET is the result of replication, not compensation. ②SET increases skin blood flow, therefore enlarges the survival area of an expanded flap.