支气管肺炎及其合并心力衰竭患儿血清内源性洋地黄样因子的变化

Changes of SEDF in children with bronchopneumonia and complicating heart failure

采用放射免疫法测定 51例正常小儿、54例支气管肺炎患儿和 2 0例支气管肺炎合并心力衰竭患儿血清内源性洋地黄样因子 (SEDF)浓度。结果支气管肺炎组SEDF高于正常对照组 (P <0 0 5) ,支气管肺炎组 54例患儿中 1 4例恢复期其SEDF浓度较急性期下降 (P <0 0 5)。且SEDF浓度和青紫成正相关 (r =0 367,P <0 0 5)。提示支气管肺炎患儿SEDF浓度增高可能和缺氧致EDF代偿增多有关。支气管肺炎合并心力衰竭组SEDF低于支气管肺炎组 (P <0 0 5) 。

Endogenous digitalis like factor (EDF) is an endogenous substance which has digitalis like biological activity Via radioreceptor assay,the concentrations of serum EDF (SEDF) were measured in 51 normal children and 54 children with bronchopneumonia or 20 children with bronchopneumonia complicating heart failure to search for the changes among them The results showed that the mean concentration of SEDF in children with bronchopneumonia was significantly higher than that in normal control group ( P <0 05),when the children recovered,the mean concentration of SEDF consequently decreased ( P <0 05) And concentrations of SEDF positively correlated with cyanosis ( r =0 367, P <0 05) It indicated that hypoxaemia may be stimulate for releasing of EDF Our study also showed that the mean concentration of SEDF in children with bronchopneumonia complicating heart failure was significantly lower than that in bronchopneumonia group