COX-2、VEGF-C在乳腺癌中的表达及临床意义

Expression and Clinical Significance of COX-2 and VEGF-C in Breast Cancer

目的研究环氧化酶．2（COX-2）、血管内皮生长因子c（VEGF-C）蛋白在乳腺癌中的表达及其临床意义。方法应用免疫组织化学SP法分别检测64例乳腺浸润性导管癌及15例乳腺纤维腺瘤组织中COX-2和VEGF-C蛋白的表达。结果乳腺癌组织中COX-2和VEGF-C蛋白阳性表达率分别为73．4％和65．6％，均明显高于乳腺纤维腺瘤组织（P〈O．01）。COX．2和VEGF．C蛋白表达与乳腺癌的临床分期、组织学分级和淋巴结转移密切相关（P〈0．05），且两者表达成明显正相关（P〈0．05）。结论COX．2和VEGF．C在乳腺癌的发生发展中起着重要的作用，检测其表达可作为反映乳腺癌生物学行为和判断预后的有效指标之一。

Objective To investigate the expression and significance of COX-2 and VEGF-C proteins in breast cancer.Methods The expression of COX-2 and VEGF-C were detected in 64 breast invasive ductal carcinona and 15 breast fibroadenoma spicemens by immunohistochemical method（SP）.Resuits COX-2 and VEGF-C positive expression rates were 73.4% and 65.6% in 64 breast carcinomas respectively,which were significantly higher than in breast fibroadenomas（P 〈 0.01）.The expressions of＇COX-2 and VEGF-C were significantly related with the clinical stages,pathologic histology grading and the metastasis of lymph node. Conclusion COX-2 and VEGF-C play important roles in the development and progress in breast cancer, which may act as one of efficient factors to indicate biological behavior and prognosis of the carcinoma.