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分化抑制因子在神经系统肿瘤中的调控作用

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摘要 分化抑制因子（inhibitor of DNA binding and／or differentiation，Id）是1990年Roben Benezra等人首先从鼠红白血病（murineerythroleukemia，MEL）细胞cDNA文库中克隆出来的一种基因，其表达产物Id蛋白属于螺旋．环一螺旋（helix—loop—helix，HLH）转录因子家族成员。
作者 董雅兰 李建峰
机构地区 河北医科大学 河北医科大学第四医院(东院)神经外科
出处 《临床神经外科杂志》 CAS 2011年第6期331-333,共3页 Journal of Clinical Neurosurgery
关键词 分化抑制因子 神经系统肿瘤 调控作用 CDNA文库 红白血病 Id蛋白 表达产物 家族成员
分类号 R739.41 [医药卫生—肿瘤]
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参考文献19

  • 1Benezra R, Davis RL, Lockshon D, et al. The protein Id : a negative regulator of Helix-Loop-Helix DNA binding proteins [ J ]. Cell, 1990, 61:49.
  • 2Ling M. T. ,Lau T. C. ,Zhou C. , et al. Overexpression of Id-1 inprostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF) [ J]. Carcinogenesis, 2005,26:1668.
  • 3李晓军,秦浚川.细胞分化抑制因子(Id)研究进展[J].生物化学与生物物理进展,2004,31(10):865-869. 被引量：29
  • 4Ouyang XS, Wang X, Ling MT, et al. Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of P16INK4a/pRB pathway [ J]. Carcinogenesis,2002,23:721.
  • 5Iavarone A and Lasorella A, Id proteins in neural cancer [ J ], Cancer Lett ,2004,204 : 189.
  • 6Fong S, Debs RJ, Desprez PY, et al. Id genes and proteins as promising targets in cancer therapy [ J ]. Trends in Molecular Medicine, 2004,10:387.
  • 7Ming-Tat L, Xianghong W, Xiaomeng Z, et al. The multiple roles of Id-1 in cancer progression[ J]. Differentiation, 2006,74:481.
  • 8Y.-C. Wong, X. Wang, M.-T. Ling. Id-1 expression and cell survival [ J]. Apoptosis ,2004,9:279.
  • 9Jurga M, Buzanska L, Malecki M, et al. Function of ID1 protein in human cord blood-derived neural stem-like cells[ J]. J Neurosci Res,2006,84:993.
  • 10Wang S, Sdrulla A, Johnson J E, et al. A role for the helix-loop- helix protein Id2 in the control of oligodendrocyte development [ J]. Neuron,2001,29:603.

二级参考文献87

  • 1李晓军,秦浚川.细胞分化抑制因子(Id)研究进展[J].生物化学与生物物理进展,2004,31(10):865-869. 被引量：29
  • 2Singh J, Murata K, Itahana Y, et al. Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex.Oneogene, 2002, 21 (12): 1812 ～ 1822
  • 3Ling M T, Wang X, Ouyang X S, et al. Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth. Oncogene, 2002, 21 (55): 8498 -8505
  • 4Ling M T, Wang X, Ouyang X S, et al. Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells. Oncogene, 2003, 22 (29): 4498 - 4508
  • 5Benezra R, Davis R L, Lockshon D, et al. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell, 1990, 61 (1):49-59
  • 6Norton J D. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci, 2000, 113 (Pt.22): 3897 - 3905
  • 7Ruzinova M B, Benezra R. Id proteins in development, cell cycle and cancer. Trends Cell Biol, 2003, 13 (8): 410 -418
  • 8Yokota Y, Mori S. Role of Id family proteins in growth control. J Cell Physiol, 2002, 190 (1): 21 -28
  • 9Ohtani N, Zebedee Z, Huot T J, et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.Nature, 2001, 409 (6823): 1067 - 1070
  • 10Yates P R, Atherton G T, Deed R W, et al. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J, 1999, 18 (4): 968 -976

共引文献37

临床神经外科杂志
2011年 第6期

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