血ADM TGF-β1在2型糖尿病肾病患者的变化及意义

The Change of Serum ADM TGF-β1 and its Clinical Sgnificance in Type Ⅱ Diabetics Nephropathy

目的:探讨血清ADM、TGF-β1在各期糖尿病肾病中的变化及在糖尿病肾病进展中的临床意义。方法:67例2型糖尿病患者根据24 h尿白蛋白排泄率(UAER)分为3组:正常蛋白尿组、微量蛋白尿组和临床蛋白尿组。分别检测糖尿病组和20例正常对照组血清ADM、TGF-β1水平。结果:①糖尿病组血ADM、TGF-β1较正常对照组明显增高(P<0.05)。②微量蛋白尿组血ADM、TGF-β1较正常蛋白尿组明显增高(P<0.05),临床蛋白尿组血ADM、TGF-β1较微量蛋白尿组明显增高(P<0.05)。③血ADM、TGF-β1与UAER呈正相关(r=0.674,P<0.01)。结论:①血ADM、TGF-β1可能在糖尿病肾病发病中起重要作用。②糖尿病正常蛋白尿组血ADM即升高,血ADM可能成为更早期糖尿病肾病的敏感指标,对监测肾病进展有重要意义。

Objective： To test the change of serum ADM,transforming growth factor beta- β1（TGF- β1 ） and investigate their clinical significances in type 2 diabetic nephropathy（DN）. Method： 67 cases of patients with type 2 diabetes according to their urinary albumin excretion rate （UAER） were divided into three groups： normal albuminuria group, microalbuminuria group and clinical proteinuria. Serum ADM,TGF- 61 levels were detected in 67 patients with type 2 diabetes and 20 normal controls. Result ： ① Serum ADM,TGF - 131 levels significantly increased in diabetic patients compared with that in normal controls（P〈 0.05）. ②Serum ADM,TGF- β1 in microalbuminuria group was significantly higher than that of normal albuminuria group（P 〈 0.05）. Com- pared with microalbuminuria group, Serum ADM,TGF- β1 was significantly higher in clinical proteinuria group （ P 〈 0.05 ）. ③ Serum ADM, TGF - β1 levels was highly correlated wit h UAER （ r = 0.674, P 〈 0.01 ）. Conclusion： （DADM,TGF- β1 was probably involved in the process of pathophysiology in type 2 diabetic nephropathy. QSerum ADM was significantly increased in normal albuminuria group and it might be an early marker for predicting diabetic nephropathy and assessing its severity.