诱导型一氧化氮合酶在喉癌中的表达及其临床意义

Expression and clinical significance of inducible nitric oxide synthases in laryngeal carcinoma

目的:观察诱导型一氧化氮合酶(inducible nitric oxide synthases,iNOS)在喉癌组织中的表达,探讨iNOS在喉癌侵袭转移中的作用。方法:应用免疫组织化学S-P法检测66例喉癌组织及其癌旁正常组织中iNOS的表达情况,并分析其表达与喉癌患者临床分期、病理分级、淋巴结转移等方面的关系。结果:iNOS在喉癌组织中表达率为81.82%,高于癌旁正常组织的6.06%(P<0.05)。不同临床分期、临床分型喉癌患者的iNOS表达率差异有统计学意义(P<0.05),而在年龄、病理分级以及淋巴结转移方面差异无统计学意义(P>0.05)。结论:iNOS可能是喉癌侵袭转移机制中的重要肿瘤标志物,在喉癌的淋巴结转移中具有一定作用,对于喉癌淋巴结转移的判断具有重要意义。

Objective：To observe the expression of inducible nitric oxide synthases（iNOS） in laryngocarcinoma tissues and its role in the invasion and metastasis of laryngeal carcinoma.Methods：The expression of iNOS in 66 cases of laryngealcarcinoma tissues and the normal mucous membrane were detecdted by immunohistochemistry S-P method.The correlation between the expression of iNOS and the clinical stage,clinical classification,pathological grade and lymph node metastasis of laryngeal carcinoma was analyzed.Results：The positive rate of iNOS in laryngealcarcinoma tissues and the normal mucous membrance was 81.82% and 6.06%,respectively（P0.05）;the expression of iNOS was significantly correlated with the clinical stage and classification of patients with laryngeal carcinoma（P0.05）,but had no relation with the patients′age,pathological grade or lymph node metastasis（P0.05）.Conclusions：iNOS may act as an important tumor marker in lymph node metastasis of laryngeal carcinoma.It plays an important role in the invasion,metastasis and prognosis of laryngeal carcinoma.