^(125)Ⅰ食管支架治疗晚期食管癌

Treatment of Advanced Esophageal Carcinoma with ^(125)-idoine Seed Stents

目的对比携带251Ⅰ粒子食管内照射支架与普通食管支架治疗晚期食管癌的临床应用效果。方法 38例晚期食管癌患者分为A、B 2组。A组18例为使用125Ⅰ粒子食管内照射支架实验组,B组20例为应用普通食管支架对照组,对2组患者术后吞咽困难缓解程度、术后并发症、外周静脉血白细胞、生存期等指标进行对比观察,确定125Ⅰ粒子食管内照射支架的安全性及疗效。结果 A、B 2组患者支架植入成功率均为100.0%,术后吞咽困难缓解程度、术后并发症、外周静脉血白细胞等指标无显著性差异(P>0.05),A组的平均生存期为11.6个月,明显长于B组的6.4个月(P<0.01)。结论 125Ⅰ粒子食管内照射支架临床应用安全有效,随访结果示其疗效优于普通支架,可明显延长晚期食管癌患者生存期。

Objective To compare the clinical effects of esophageal intraluminal 125-idoine seed irradiation stents and general esophageal stents on advanced esophageal carcinoma.Methods Thirty-eight patients with advanced esophageal carcinoma were treated with esophageal intraluminal 125-idoine seed irradiation stents（group A,18 patients）or general esophageal stents（group B,20 patients）.Dysphagia score,complications,peripheral blood leukocytes and life-span were compared between the two groups after stent implantation to investigate the safety and effectiveness of 125-idoine seed stents.Results The success rates of stent implantation were 100.0% in both groups.There were no significant differences in postoperative dysphagia score,complications and peripheral blood leukocytes between the two groups（P0.05）.The mean survival time in group A was obviously longer than that in group B（11.6 months vs 6.4 months,P0.01）.ConclusionEsophageal intraluminal 125-idoine seed irradiation stents are safe and effective and can prolong the life-span in patients with advanced esophageal carcinoma.