谷氨酸钠对家兔体温的影响及其机制的研究

Study on the effect of monosodium glutamate on the body temperature and its mechanism in rabbit

本实验用58只封闭群新西兰白兔,观察了MSG降低正常体温的剂量效应关系,以及心得安和654-2对其降温效应的影响。结果表明,小剂量(0.1g/kg.w)MSG对正常体温没有明显影响,中等剂量(0.5g/kg.w)和大剂量(1.0g/kg.w)都能明显降低体温,但从总的体温反应效应来看(△T、TRI_5),中等剂量组较高。用β-受体阻断剂心得安预处理动物,MSG降低正常体温的作用未受到有意义的影响;但胆碱能神经阻断剂S54-2能明显阻断MSG的降温作用。作者认为,MSG可能是通过胆碱能神经影响正常体温。

With 58 of New Zeeland rabbits, following experiments were carried out: (1) the dose-response relationship of MSG which decreased the body temperat ure; (2) the effects of the propranolol and the anisodamine (654-2) on the action of decreasing body temperature by MSG. The results indicated: following intravenous administration of MSG at a dose of 0.5g/kg. w and 1.0g/kg. w, the body temperature of rabbits were decreased significantly, but at a dose of 0.1g/kg.w, the change of temperature was insignificant.Pretreatment with propranolol did not affect the effect of MSG decreasing body temperature which was blocked significantly by anisodamine, one of blocker of the cholinergic nerve. The authors suggest that the effect of MSG decreasing body temperature may depend on the cholinergic nerve.