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甲基化-CpG-结合蛋白家族在肿瘤等疾病中的研究 被引量：1

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摘要 甲基化-CpG-结合蛋白（methyl-CpG-bindingprotein 2,MeCP2）最早由R.R.Meehan等[1]提出,它是一种含特异性序列的DNA结合蛋白。随后,在哺乳动物中发现有一组蛋白每个都包含与MeCP2中甲基化-CpG-结合序列（methyl-CpG-bindingdomain，MBD）相同的基本结构，并将这组蛋白统称为甲基化-CpG-结合蛋白家族（methyl-CpG-bindingproteins，MBDs）。
作者 邓薇 王枫 习斌蓉
机构地区 江西省妇幼保健院科教科 江西省妇幼保健院中心实验室
出处 《南昌大学学报（医学版）》 CAS 2011年第12期101-103,共3页 Journal of Nanchang University：Medical Sciences
关键词 甲基化-CpG-结合蛋白家族 表观遗传学 肿瘤
分类号 Q513 [生物学—生物化学]
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参考文献18

  • 1翁文浩,李智.甲基化CpG结合蛋白2在肿瘤发生中的作用研究[J].检验医学,2009,24(8):622-625. 被引量：2
  • 2Kondo E,Gu Z,Horii A,et al.The thymine DNA glycosylaseMBD4represses transcription and is associated with methyla-ted p16 (INK4a)and hMLH1genes. Molecular and Cellular Biology . 2005
  • 3Bulun S E.Endometriosis. The New England Journal of Medicine . 2009
  • 4Chatagnon A,Bougel S,Perriaud L,et al.Specific associationbetween the methyl-CpG-binding domain protein 2and thehypermethylated region of the human telomerase reversetranscriptase promoter in cancer cells. Carcinogenesis . 2009
  • 5Morey L,Brenner C,Fazi F,et al.MBD3,a component of theNuRD complex,facilitates chromatin alteration and deposi-tion of epigenetic marks. Molecular and Cellular Biology . 2008
  • 6Sansom O J,Berger J,Bishop S M,et al.Deficiency of Mbd2suppresses intestinal tumorigenesis. Nature Genetics . 2003
  • 7Xue Q,Lin Z,Yin P,et al.Transcriptional activation of steroi-dogenic factor-1by hypomethylation of the 5’’CpG island inendometriosis. The Journal of Clinical Endocrinology . 2007
  • 8Ohki I,Shimotake N,Fujita N,et al.Solution structure of the Methyl-CpG binding domain of human MBD1 in complex with methylated DNA. Cell . 2001
  • 9Snape A.MBDs mediate methylation, deacetylation and transcriptional repression. Trends in Genetics . 2000
  • 10Detich N,Theberge J,Szyf M.Promoter-specific activation and demethylation by MBD2/demethylase. Journal of Biological Chemistry . 2002

二级参考文献27

  • 1Ng HH, Zhang Y, Hendrich B, et al. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex [J]. Nat Genet, 1999, 23(1) :58-61.
  • 2Feng Q, Zhang Y. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes [ J ]. Genes Dev, 2001, 15(7) :827-32.
  • 3Marhold J, Brehm A, Kramer K. The Drosophila methyl- DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2 [ J]. BMC Mol Biol, 2004, 5(1):20.
  • 4Detich N,Theberge J,Szyf M. Promoter-specific activation and demethylation by MBD2/demethylase [ J ]. J Biol Chem, 2002, 277 (39) :35791-35794.
  • 5Fujita H, Fujii R, Aratani S, et al. Antithetic effects of MBD2a on gene regulation [ J]. Mol Cell Biol, 2003, 23 (8) : 2645-2657.
  • 6Lembo F, Pero R, Angrisano T, et al. MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters[ J]. Mol Cell Biol, 2003, 23 (5) :1656-1665.
  • 7Angrisano T, Lembo F, Pero R, et al. TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters [J]. Nucleic Acids Res, 2006, 34(1):364- 372.
  • 8Sekimata M, Homma Y. Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF[J]. Nucleic Acids Res, 2004, 32(2):590-597.
  • 9Fukushige S, Kondo E, Gu Z, et al. RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression [ J ]. Biochem Biophys Res Commun, 2006, 351 ( 1 ) :85-92.
  • 10Brackertz M, Gong Z, Leers J, et al. p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction [ J 1. Nucleic Acids Res, 2006, 34(2) :397-406.

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南昌大学学报（医学版）
2011年 第12期

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