肢体动脉硬化性闭塞症病毒感染相关性中医研究

CORRELATIVE STUDY ON VIRUAL INFECTION IN ARTERIOSCLEROTIC OBLITERATION WITH TRADITIONAL CHINESE MEDICINE(TCM)

利用聚合酶链反应 (PCR)、免疫荧光技术和电镜技术 ,对肢体动脉硬化性闭塞症 (ASO)患者的血液和血管组织进行检测 ,发现巨细胞病毒的感染及基因表达率分别为 42 .5 9% ,2 8.95 % ,较对照组具有非常明显的差异(P<0 .0 1)。同时 ,应用解毒祛瘀法进行中西医结合临床治疗 ,取得良好疗效。研究证实 :1巨细胞病毒感染是造成ASO的始动病因 ;2“邪毒”是造成 ASO瘀滞的病因机制。

The blood and blood vessel tissues in patients with arteriosclerotic obliteration(ASO) were determined by polymerase chain reaction(PCR),immuno fluorescence technique(IFT) and electron microscopy.The results showed the rate of genetic expression of cytomegalovirual infection in ASO patients was 42.5%,which was higher than that in normal human(P<0.01).According to the therapeutic principle of removing toxic substances and blood stasis,ASO patients were treated with integration of western and Chinese medicine,and well therapeutic effects has been obtained.It indicated that: ①cytomegalovirual infection was the primary cause of ASO;②pathogenic toxin was the pathogenesis that leaded to blood stasis in ASO patients. [