摘要
目的:探讨流行性腮腺炎合并睾丸炎有效的治疗方法。方法:选择2008年11月～2010年8月本院住院患者60例,随机分成两组,治疗组35例,对照组25例,治疗组应用α-2b干扰素(凯因益生,北京凯因生物技术有限公司)3000000U每日1次肌注,连用5d;对照组给予利巴韦林注射液10mg/(kg·d),最大量至600mg,加入5%葡萄糖液中静滴,连用7d。观察两组疗效。结果:治疗组患者退热时间、腮腺及睾丸消肿时间、血、尿淀粉酶恢复时间显著缩短,分别为(1.6±0.8)、(2.7±2.9)、(4.3±1.6)、(3.0±1.1)、(4.1±1.9)d、明显优于对照组的(2.4±1.0)、(8.0±5.0)、(6.2±2.8)、(5.1±1.9)、(6.4±1.1)d,经t检验,P<0.01。治疗过程中未发现不良反应。结论:肌内注射小剂量α-2b干扰素治疗腮腺炎合并睾丸炎是一种安全有效的方法。
Objective： To explore the effective treatment of epidemic mumps orchitis. Methods： Sixty patients from November 2008 to August 2010 were slected and were divided into treatment group and control group, the treatment group 35 cases were given 3 000 000 U of Interferon α-2b （Kain prebiotics, by Beijing Kain Biotechnology Co., Ltd.） intramuscularly once a day for 5 days and 25 patients in the control group were given 10 mg/（kg.d） ribavirin injection with maximum dose of 600 mg in combination with 5% glucose solution intravenously for 7 days. Results： Fever clearance time, parotid gland and testicular swelling subsidence time and blood and urine amylase recovery time were （1.6±0.8）, （2.7±2.9）, （4.3±1.6）, （3.0±1.1） and （4.1±1.9） days respectively in the treatment group and were significantly shorter than （2.4±1.0）, （8.0±5.0）s, （6.2±2.8）, （5.1±1.9） and （6.4±1.1） days in the control group. The differences were found to be significant in t-test （P〈0.01）. No adverse reactions were found in the course of treatment. Conclusion： Intramuscular injection of small doses of interferon α-2b is an effective treatment of mumps orchitis.
出处
《中国当代医药》
2011年第35期83-83,85,共2页
China Modern Medicine
