Nogo-A蛋白及Nogo受体抑制剂防治中枢神经系统疾病的研究进展

Advances of Nogo-A protein and Nogo receptor inhibitors on the prevention and control of central nervous system diseases

缺氧缺血、感染、脱髓鞘等多种因素均可造成儿童中枢神经系统损害,严重威胁儿童生命和健康,死亡率和致残率高。传统的观点认为中枢神经损伤后不能再生。研究证实,阻止中枢神经损伤后再生的重要原因是中枢神经的内环境中存在抑制神经再生的因子。其中,Nogo-A蛋白及其受体发挥着重要作用,近年来关于Nogo-A、Nogo受体及其抑制剂在中枢神经系统损伤和再生方面取得不少研究进展,现加以总结。

Many pathogenies can lead to the injury of central nervous system （CNS） of children, such as hypoxia-ischemia, infection and demyelination, thus exert servious threat to the life and health, and with a high mortality and disability rate. Traditional idea maintained that central nervous system can not regenerate after damage. However, series of proved those inhibitory factors that exist in the microenviroment served as the funderental cause for the prevention of CNS regeneration after injury. Among them Nogo-A and its receptor plays a vital role. In recent years, quite a few research progress has been made of the effect of Nogo-A, Nogo receptor and its specific antagonist on CNS injury and regeneration, just as the following summary.