两种中西医结合方案治疗下尿路感染的药物经济学分析

Pharmacoeconomic Analysis of Two Integrated Traditional and Western Treatment Formulas of Lower Urinary Tract Infection

目的:探讨两种不同用药方案(方案A:乳酸左氧氟沙星氯化钠注射液0.4g,静脉滴注,每日1次,连续3日;静脉给药后改为联合服用乳酸左氧氟沙星片剂和热淋清颗粒(规格:4g×8袋,贵州威门药业股份有限公司,批号:100203)。其中,乳酸左氧氟沙星片,0.2g,口服,每日2次,连续7日;热淋清颗粒,8g,开水冲服,每日3次,连续7日。方案B:注射用乳糖酸阿奇霉素0.5g,加入250mL生理盐水,静脉滴注,每日1次,连续3日;静脉给药后改为联合服用阿奇霉素分散片和热淋清颗粒。其中,阿奇霉素分散片,0.2g,每日1次,口服3天,停1天,再口服3天;热淋清颗粒,8g,开水冲服,每日3次,连续7日。)治疗下尿路感染的临床效果,并进行成本-效果分析,为临床选择最佳给药方案提供依据。方法:两种治疗方案的临床观察由航空总医院泌尿外科完成,统计共48例急性下尿路感染门诊病例的症状积分,采用药物经济学中的成本-效果分析法,对各方案进行药物经济学分析评价。本研究采用成本/疗效指数(C/EI)比较,不仅能得到与传统的成本/效果(C/E)比较同样的结果排序,而且还可以得到各组间的统计学差异。结果:治疗下尿路感染的诸方案中,方案A的总成本为403.25元,总有效率为96.0%,成本/效果比为4.38,成本/疗效指数比为440.47±68.11;方案B的总成本为523.81元,总有效率为86.9%,成本/效果比为5.46,成本/疗效指数比为585.80±129.36。因此,方案A具有更高的有效率以及更低的成本/效果比和成本/疗效指数比。结论:本研究结果提示:对于下尿路感染,给药方案A具有较佳的成本-效果比,值得临床推广。

Objective： To evaluate the clinical effectiveness of 2 different integrated traditional and western treatment formulas for treating lower urinary tract infection and provide evidence for chnician to choose medicine by cost - effectiveness analysis. Methods ： The clinical observation of 2 different treatment formulas was finished by urinary surgery of Aviation Central Hospital. By counting the therapeutic indices of 48 outpatient cases and using cost - effectiveness analysis of pharmacoeconomics to evaluate these treatment formulas. Result： The formula A was the best one for its cost is RMB 403.25 and its efficient is 96%. Conclusion： The formula A in the treatment of lower urinary tract infection was more in- expensive and an effective scheme.