房颤中医证型与患者心功能及炎症因子的相关性研究

Investigation on Relationship Between Types of Syndrome of AF and Heart Function And Inflammatory Factors of Patients with Atrial Fibrillation

目的:探讨房颤中医证型与患者BNP、LVEF、FS、E峰、A峰、E/A和炎症因子CRP、TNF-α、IL-6的相关性。方法:入选房颤患者92例,根据房颤中医证型标准分为5型,分别比较BNP,LVEF,FS,E峰,A峰、E/A以及炎症因子CRP、TNF-α、IL-6在中医证型间的差别。结果:房颤组E峰,E/A低于对照组(P<0.05),CRP、TNF-α、IL-6高于对照组(P<0.05),BNP显著高于对照组(P<0.01);证型间比较显示:心阳不振型房颤LVEF、FS、E峰、E/A低于其他证型(P<0.05);TNF-α、IL-6高于其他证型(P<0.05),BNP显著高于其他证型(P<0.01);结论:心阳不振型房颤合并心功能减低,且该型房颤炎症反应明显。

Objective ： to discuss relationship between Atrial Fibrillation TCM types of syndrome and BNP, LVEF, FS, E peak, A peak, E/A and inflammatory factors CRP, TNF and IL - 6 of patients with AF. Method： 92 patients with AF were divided into 5 groups according to TCM differentiation, compared the differences of LVEF, FS, E peak, A peak, E/A, CRP, TNF - α, IL - 6 and BNP among the 5 types of TCM syndrome and the difference between AF group and con tral group. Results ： E peak, E/A of AF group are lower than those of the control group, CRP. TNF - α. IL - 6 are higher than those in the control group （P 〈 0.05 ）. BNP is higher than that of control group markedly（ P 〈 0. 01 ） ; LVEF, FS, E peak, and E/A of heart yang debilitation AF are lower than that of other types（P 〈 0.05 ） ;TNF -α and IL -6 are higher than other types （P 〈 0.05 ）. BNP is higher than that of other types markedly （ P 〈 0.01 ） . Conclusion ： Heart yang debilitation AF combined with heart function reduction and obvious inflammatory response.