西格列汀联合甘精胰岛素治疗2型糖尿病疗效观察

Effect observation of Sitagliptin combined insulin glargine in treatment of type 2 diabetes

目的观察甘精胰岛素联合西格列汀治疗2型糖尿病的有效性及安全性。方法将2型糖尿病患者90例随机分为观察组和对照组各45例。观察组给予甘精胰岛素联合西格列汀治疗,对照组给予甘精胰岛素治疗,治疗6周后比较两组患者治疗前后糖化血红蛋白(HbA1c)、餐后2h血糖(2hPG)、空腹血糖(FBG)水平及临床疗效。结果两组患者治疗后观察组总有效率为86.7%,高于对照组的71.1%(P<0.05);且治疗后HbA1c、2hPG、FBG水平均下降(P<0.05),且观察组下降更显著,差异有统计学意义(P<0.05)。结论甘精胰岛素联合西格列汀患者依从性好,低血糖事件发生率低,能有效地控制血糖,是一种较为理想联合治疗方法。

Objective To observe the efficacy and safety of combined insulin glargine treatment of type 2 diabetes,sitagliptin.Methods Totally 90 patients with type 2 diabetes were randomly divided into two groups and the control group 45 cases in each group.Observation group received insulin glargine combined sitagliptin treatment,control group received insulin glargine therapy,treatment for 6 weeks after the two groups were compared before and after treatment in patients with glycosylated hemoglobin（HbA1e）,2h postprandial blood glucose（2hPG）,fasting blood glucose（FBG） levels and clinical efficacy.Results Two groups after treatment,total effective rate was 86.7% higher than the 71.1%（P0.05）;And after treatment,HbA1c,2hPG,FBG levels were decreased（P0.05）,and the observation group decreased more significant,the difference was statistically significant（P 0.05）.Conclusions Insulin glargine in patients with good compliance and co-sitagliptin,a low incidence of hypoglycemic events,can effectively control blood sugar,is an ideal combination therapy.