脑梗死患者颈动脉粥样硬化与尿白蛋白关系的研究

Association between urinary albumin and carotid atherosclerosis in cerebral infarction patients

目的:观察脑梗死患者尿白蛋白(UALB)与颈动脉粥样硬化的关系。方法:将100例脑梗死患者分为UALB阳性组58例和UALB阴性组42例,比较2组患者尿白蛋白排泄的变化、颈动脉超声检测结果以及二者之间的关系。结果:UALB阳性组患者颈总动脉内膜中层厚度、粥样斑块出现率均高于UALB阴性组患者,尿白蛋白排泄水平升高,粥样斑块出现率升高(P<0.05),内膜中层厚度与UALB、血总胆固醇、糖基化血红蛋白、血尿酸(UA)等呈正相关,而内径与UA、UALB呈负相关。结论:UALB阳性患者易出现颈动脉粥样硬化,当尿白蛋白排泄≥60 mg/24 h时危险性进一步增加。

Objective ：To observe the relationship between urinary albumin（UALB） and carotid atherosclerosis in cerebral infarction patients. Methods：One hundred patients with cerebral infarction were divided into 2 groups：UALB positive group（n = 58） and UALB negative group（n = 42）. UALB excretion and uhrasonography for carotid artery were examined. Results： The common carotid artery intima media thickness,incidence rate of plaque were significantly higher in UALB positive group. The incidence rate of plaque was significantly higher when UALB exceeded the threshold of I〉60 mg/24 h（ P 〈 0.05 ）. The intima media thickness was positively related with the UALB, total cholesteral, and hemoglobin A1C ,while the interior diameter was negatively with uric acid and UALB. Conclusions： High incidence of carotid atherosclerosis is happened in patients with positive UALB, especially when patients with UALB t〉 60 mz./24 h.