碱性成纤维细胞生长因子联合肝素及红光疗法对促进烫伤创面愈合的作用

Basic Fibroblast Growth Factor Combined with Heparin Therapy and Red Light Therapy in Enhancing Burn Wound Healing

目的:比较3种疗法治疗深Ⅱ度烫伤创面的临床效果。方法:135例181个深Ⅱ度烫伤创面患者分为3组,A组43例58个创面采用常规生理盐水冲洗创面,庆大霉素生理盐水纱布包扎;B组47例63个创面,在常规治疗基础上给予碱性成纤维细胞生长因子(bFGF)凝胶及肝素局部涂抹治疗;C组45例60个创面,在A、B治疗方法的基础上联合局部红光照射。治疗后观察3组患者创面愈合时间及愈合率,评定临床疗效。结果:经过平均21d的治疗,创面愈合率C组>B组>A组(96.7%±4.8%,88.7%±5.1%,70.1%±11.3%,P<0.01)。结论:bFGF外用联合肝素、红光疗法可显著提高深Ⅱ度烫伤创面的临床效果,增加愈合率,缩短治疗时间。

Objective： To explore the treatment effect of basic fibroblast growth factor（bFGF） combined with heparin therapy and red light therapy for deep II degree burn wounds.Methods： From February 2008 to March 2011,135 patients with deep II degree burn wounds（181 wounds）,according to gender,age,duration,burn area,drug use area,were randomly divided into three groups,which were given conventional treatment（group A）,joint heparin treatment（group B）,and joint heparin plus red light（group C）,respectively.By using SPSS 16.0 software,the clinical data were analyzed by Student t test,chi-square test and variance analysis.Results： All cases were followed up for 6-12 months（9 months on average）.The wound healing time in groups A,B and C was（28.1±6.3）,（20.9±4.5） and（16.9±3.9） days respectively（F=11.53,P0.01）.The wound healing rate in groups A,B and C was 70.1%±11.3%,88.7%±5.1%,and 96.7%±4.8% respectively（F= 8.24,P0.01）.The therapeutic effective rate in groups A、B and C was 74.1%,90.4% and 100.0% respectively（F=8.95,P0.01）.Conclusion： The bFGF combined with heparin and red light therapy can enhance deep II degree burn wound healing and shorten the treatment duration.