血清降钙素原检测在婴幼儿社区获得性肺炎诊断和治疗中的价值探讨

Significance of serum PCT in the diagnosis and treatment of infant community acquired pneumonia

目的探讨降钙素原(PCT)在婴幼儿肺炎诊断和治疗中的意义。方法 84例社区获得性肺炎患儿入选,抽取患者第1天、第7天的静脉血离心,留取血清保存于-20℃待测,采用免疫荧光定量分析法检测PCT水平,用终点散射比浊检测血浆CRP水平,同时对患儿外周血白细胞进行计数。结果 64例细菌性肺炎患者PCT、CRP、WBC明显高于非细菌性感染患者,重症肺炎PCT结果均在0.5ng/ml以上,有3例>10ng/ml,明显高于普通肺炎,64例细菌性肺炎患者入院时血清PCT阳性率为81.3%,随着炎症的控制和病情的缓解,住院第7天,PCT检测阳性率下降为32.8%。结论血清PCT、CRP值和细菌感染密切相关,血清PCT水平对病情的轻重程度有一定的评估作用,对指导临床合理使用抗生素、疗效判断有重要参考意义。

Objective To explore the significance of serum PCT in the diagnosis and treatment of infant community acquired pneumonia.Methods The blood samples of 84 cases of community acquired pneumonia were drawn out for PCT and CRP on the first day and the seventh day in patient department.PCT were determined by immuno-fluorescence quantity,CRP were measured by using nephelometry turbidity method,white blood test were counted at the same time.Results The level of PCT and CRP and WBC in 64 cases of bacterial pneumonia were obviously higher than in the non-bacterial cases.The level of PCT in severe pneumonia was higher than 0.5mg/ml,which were higher than common pneumonia and it was higher than 10mg/ml of three cases.The positive rate in 64 cases was 81.3% and it decreased to 32.8% on the seventh day after infection control.Conclusion Serum PCT and CRP were closely related to bacterial infection.The level of serum PCT show a significant co-relation with the stage of the disease.It played an important reference value to reasonable use of antibiotics therapeutic effect evaluating.