杂合肾脏替代治疗鱼胆中毒合并急性肾损伤患者疗效的研究

Hybrid renal replacement therapy in acute fish bile poisoning with acute kidney injury

目的本研究旨在观察杂合肾脏替代治疗(hybrid renal replacement therapy,HRRT)在鱼胆中毒致急性肾损伤(AKI)中的应用效果。方法回顾分析以HRRT方法治疗我科今年收治的8例鱼胆中毒患者,HRRT采用持续缓慢低效血液透析(sustained low-efficiency dialysis,SLED)联合血液灌流(HP)的模式。分别进行3～5次的治疗。观察患者治疗前后相关指标变化。结果 8例患者经HRRT治疗后,相关指标明显改善,肾功能均完全恢复。结论鱼胆中毒所致严重并发症AKI早期积极采用SLED联合HP治疗能获得满意疗效。

Objective The aim of this study is to observe the effect of hybrid renal replacement therapy with hemoperfusion on acute fish bile poisoning with acute kidney injury.Methods We designed a retrospective analysis which enrolled eight patients who developed AKI after acute fish bile poisoning and treated with HRRT 3-5 times this year in our department.The patients were observed before and after treatment indexes to change.Resuts All patients had a sharp improvement in all index of correlation after therapy,their renal function recovery.Conclusion AKI is a severe complication of acute fish bile poisoning,and active SLED＋HP as early intervention can bring significant benefits.