联合缬沙坦治疗高血压慢性充血性心力衰竭的临床研究

Clinical treatment about hypertension chronic congestive heart failure combined with valsartan

目的在标准治疗基础上联用缬沙坦治疗高血压慢性充血性心力衰竭与标准治疗的疗效比较。方法选择高血压致慢性充血性心力衰竭的患者368例,随机分为对照组和实验组,每组184例。对照组按照"2007年慢性心力衰竭诊断治疗指南"的标准治疗。实验组为在标准治疗的基础上加用缬沙坦80mg/d,随访半年。观察两组患者心功能改善情况和并发症的发生情况以判断疗效。结果与对照组比较,实验组心功能有明显改善(P<0.05);脑卒中和新发糖尿病发生率低(P<0.05)。结论在标准治疗基础上联用缬沙坦治疗高血压慢性充血性心力衰竭疗效优于标准治疗组。

Objective To compare the application effect of standard treatment and combined with valsartan on hypertension chronic congestive heart failure.Methods 368 patients were randomly divided into control group and experiment group,184 patients in each group.Control group was treated according to guide line for chronic congestive heart failure in 2007,experiment group was treated by standard treatment and valsa-rtan（80mg/d）,follow-up half a year.Treatment effect was observed and compared.Results Compared with control group,cardiac function was improved（P〈0.05）;stroke and new-onset diabetes rates was lower（P〈0.05）.Conclusion Curative effect is better than standard treatment group compared with experiment group.