慢性阻塞肺病急性加重期应用孟鲁司特的临床观察

Clinical analysis of Montelukast sodium angainst acute exacerbation chronic obstructive pulmonary disease

目的观察慢性阻塞性肺疾病急性加重期应用孟鲁司特的疗效。方法将40例诊断慢性阻塞性肺病缓解期的患者随机分为对照组和治疗组。对照组采用吸氧、抗感染、止咳、化痰等常规治疗,而治疗组在常规治疗基础上加用孟鲁司特钠10mg每晚1次,疗程为7d。比较治疗前后两组患者咳嗽症状、血气分析的变化。结果与对照组相比,治疗组咳嗽症状有更明显的改善(P=0.29),动脉二氧化碳分压有所降低(P=0.037),而氧分压无明显变化(P=0.235)。结论孟鲁司特钠对进一步改善慢性阻塞性肺疾病急性加重期的患者病情有效。

Objective To investigate the efficacy of Montelukast sodium on treatment of acute exacerbation chronic obstructive pulmonary disease（AECOPD）.Methods 40 patients with AECOPD were divided into two groups randomly.All patients were routinely treated by oxygen inhalation,antibiotics,cough relieving and eliminating sputum.On the basis of roution,and ibiotics,cough relieving and eliminating sputum.On the basis of routine therapy,the treatment group was added oral Montelukast sodium（10mg q n）.After 7d treatment,the symptoms and blood gas analysis were performed.Results After 7d treatment,cough was improved and partial pressure of CO2 were decreased in treatment group compared with the controls.But the improvement of partial pressurs of O2 between the two groups was not significant.Conclusion Montelukast sodium is effective in the treatment of AECOPD.