脑梗死患者外周血中IL-2、IFN-γ、CRP的变化及临床意义

Change of IL-2,IFN-γ,CRP in peripheral blood of acute cerebral infarction and its clinical significance

目的观察脑梗死患者血清中IL-2、IFN-γ、CRP的水平变化,探讨其与脑梗死体积大小以及神经功能恢复的相关性。方法选取我科42例急性脑梗死患者作为病例组,并随访3个月。观察其发病第3天、第7天、第14天血清中IL-2、IFN-γ、CRP水平变化,并比较病例组中不同梗死体积患者之间的差别。对病例组患者入院时进行NIHSS评分以及随访3个月后进行改良Rankin评分。分析病例组发病第3天IL-2、IFN-γ、CRP的水平与NIHSS评分和改良Rankin评分的相关性。同时选取我院健康体检者24名作为对照组,检测其血清中IL-2、IFN-γ、CRP水平。结果第3天、第7天、第14天病例组患者血清中IL-2、IFN-γ、CRP的水平均升高,且高于对照组(P<0.05)。随着时间的延长,病例组患者血清中IL-2、IFN-γ、CRP的水平逐渐降低。大体积脑梗死患者第3天IL-2、IFN-γ、CRP含量明显高于中小体积梗死患者(P<0.05)。第3天病例组血清IL-2、IFN-γ、CRP含量与入院时NIHSS评分、改良Rankin评分呈正相关(P<0.05)。结论急性脑梗死患者血清IL-2、IFN-γ、CRP含量高低可反映患者严重程度,并评估预后。

Objective To investigate the serum levels of IL-2, IFN-γ, CRP in patients with acute cerebral infarction （ACI） and study the relationship between these levels and the size of infarct volume as well as early functional recovery. Methods Forty-two patients with admitted in our hospital were regarded as the study group and followed up for 3 months. The serum levels of IL-2, IFN-γ, CRP were measured 3, 7, 14 days after the onset of ACI, and difference between patients with different infarction volume were analyzed. The patients were evaluated by NIHSS on the admission day and by Rankin scale 3 months after discharge. 24 healthy individuals were enrolled as the control group, with the levels of IL-2, IFN-γ, CRP measured. Results In the study group, the serum levels of IL-2, IFN-γ, CRP increased 3, 7, 14 days after the onset of ACI, significantly higher than those in the control group （P0.05）; The serum levels of IL-2, IFN-γ CRP gradually decreased with increase of time. The levels of IL-2, IFN-γ, CRP in patients with big mass cerebral infarction were significantly higher than those in the patients with small mass cerebral infarction （P0.05）. The levels of IL-2, IFN-γ, CRP 3 days after the onset of ACI were positively related with NIHSS and Rankin scale （P0.05）. Conclusion The serum levels of IL-2, IFN-γ, CRP would be helpful for estimating the severity of acute cerebral infarction and the prognosis.