夫精宫腔内人工授精周期数与妊娠率的相关性分析

Correlation analysis on the pregnancy outcome and cycles of intrauterine insemination with husband sperm

目的分析夫精宫腔内人工授精(IUI)治疗周期数与临床结局的相互关系。方法回顾性分析2196个IUI周期的病例资料,比较治疗周期次数与临床妊娠率的关系。结果 1625例患者行2196个IUI周期,有329例获临床妊娠,周期妊娠率为15%,夫妇累积妊娠率为20.2%。第1、第2、第3、第4周期组的临床妊娠率分别为15.2%、14.9%、12.9%、0.0%,各组间比较差异无统计学意义(P>0.05);1、2、3、4个周期组的周期临床妊娠率分别为19.7%、10.1%、8.9%、6.3%,累积妊娠率分别为19.7%、20.2%、26.7%、25.0%。两两比较分析显示1个周期组与2个周期组及3个周期组的周期临床妊娠率差异均有统计学意义(P<0.01),但其他组间比较差异无统计学意义(P>0.05);各组间累积妊娠率比较差异无统计学意义(P>0.05)。结论 IUI治疗中适当增加助孕周期数可以增加累积临床妊娠率。

Objective To explore the correlation between the cycles of intrauterine insemination （IUI） with husband sperm and the pregnancy outcome. Methods A total of 2 196 IUI cycles were analyzed retrospectively. The relationship between the number of cycles of IUI and pregnancy rate was analyzed. Results 1 625 infertile couples were treated with 2 196 cycles of IUI. 329 cases were found with pregnancy. The pregnancy rate （PR） was 15% per cycle and 20.2% per couple. The clinical PR for the first, second, third and fourth cycle were 15.2%, 14.9%, 12.9% and 0.0%, respectively, with no statistically significant differences （P〉0.05）. The cycle PR for the one cycle, two cycle, three cycle, four cycle were 19.7%, 10.1%, 8.9%, 6.3%, respectively, with statistically significant difference between the one, two, three cycle. The cumulative pregnancy rates for the four groups were 19.7%, 20.2%, 26.7%, 25%, respec- tively, with no statistically significant differences （P〉0.05）. Conclusion Adding IUI cycles properly could increase the clinical pregnancy rate.