阿尔茨海默病患者血清甲状腺激素和胆固醇的变化

Alterations of thyroid hormones and cholesterol in patients with Alzheimer′s disease

目的:探讨阿尔茨海默病患者血清甲状腺激素和胆固醇的变化。方法:选择2009年7月～2011年7月住本院的阿尔茨海默病患者74例以及年龄性别相匹配的健康老年人74例,以化学发光法分别检测两组血清甲状腺激素[包括游离三碘甲状腺原氨酸(FT3)、三碘甲状腺原氨酸(T3)、游离甲状腺素(FT4)、甲状腺素(T4)、促甲状腺激素(TSH)]水平,以酶法检测两组血清胆固醇(CHOL)水平。结果:阿尔茨海默病组FT3[(2.49±1.34)pg/ml]和T3[(0.98±0.43)ng/ml]的水平均明显降低,分别与对照组[(2.85±0.61)pg/ml、(1.34±0.54)ng/ml]比较,差异均有统计学意义(P<0.05);与对照组TSH[(3.70±2.29)μIU/ml]比较,阿尔茨海默病患者TSH水平明显降低[(2.41±2.70)μIU/ml](P<0.05),而阿尔茨海默病患者血清胆固醇[(4.58±1.23)mmol/L]显著高于对照组[(4.12±1.21)mmol/L],差异有统计学意义(P<0.05)。结论:阿尔茨海默病患者血清甲状腺激素降低、血胆固醇升高,其机制有待进一步探讨。

Objective： To explore the alterations of thyroid hormones and cholesterol in patients with Alzheimer＇s disease （AD）. Methods： Seventy four patients with Alzheimer＇s disease and 74 healthy elders matching with age and gender were enrolled from July 2009 to July 2011, the levels of serum triiodothyronine （T3） , tetraiodothyronine （T4）, firee triiodothyronine （FT3）, free thyroxine（PT4）, and thyroid stimulating hormone （TSH） were measured by chemiluminescence, the levels of serum cholesterol were measured by enzymic method in Alzheimer＇s disease group and normal elderly group. Results： The levels of FT3 [（2.49±1.34） pg/ml] and T3 [（0.98±0.43） ng/ml] significantly decreased in AD group, compared with the control group [（2.85±0.61） pg/ml, （1.34±0.54） ng/ml] respectively, the difference was all significant （P〈0.05）. Compared with controls [（3.70±2.29） μIU/ml], the level of TSH in AD group [（2.41±2.70） μlU/ml] decreased significantly （P〈0.05）. While the level of cholesterol increased significantly in AD group [（4.58±1.23） mmol/L], compared with the control group [（4.12±1.21） mmol/L, the difference was significant （P〈0.05）. Conclusion： The level of thyroid hormones decreased and the level of cholesterol increased in patients with Alzheimer＇s disease. However, the mechanism needs further study.