C反应蛋白与慢性阻塞性肺疾病的临床相关性分析

Clinical analysis of the relationship between high-sensitivity C-reactive protein and chronic obstructive pulomonary disease

目的:探讨C反应蛋白在慢性阻塞性肺疾病急性加重期(AECOPD)病情严重程度与缓解期的临床意义。方法:测定94例慢性阻塞性肺疾病患者急性加重期及缓解期(使用ELISA法检测)空腹血清中的CRP浓度和WBC总数的变化,进行肺功能第1秒用力呼气容量FEV和1s率FEV/FVC测定,患者根据肺功能测定及临床资料评估结果将COPD病情严重程度分为Ⅳ级,分析CRP水平与各级COPD之间及加重期与缓解期之间的关系。结果:随着COPD急性加重期(AECOPD)病情的加重,血清中CRP的水平明显升高(P<0.01),AECOPD患者CRP水平明显高于缓解期(P<0.01)。结论:CRP可作为慢性阻塞性肺疾病急性加重期感染的敏感及重要指标,并与AECOPD病性严重程度分级呈正相关。

Objective： To investigate the expression situation and clinic significance of high-sensitivity C-reactive protein （CRP） in acute exacerbation （AECOPD） and remission period of chronic obstructive pulmonary disease, then to discuss the significance of them in detection of AECOPD as well as offer the serologic basis in treatment of AECOPD. Methods： De- termination of 94 cases of chronic obstructive pulmonary disease patients with acute exacerbation period and remission （use ELISA test） fasting blood serum levels of CRP levels and the change of the total number of WBC, lung function were forced expiratory volume 1 SEC FEV and 1 s rate FEV/FVC determination, the patients with lung function according to measure- ment and clinical data assessment results would be COPD in serious condition degree IV divided into level, analyzed and all levels of COPD CRP between time and increase and the relationship between the remission. Results： With COPD acute exacerbation （AECOPD） disease in serum of the deterioration of the CRP level increased significantly （P〈0.01）, AECOPD CRP level in patients with significantly higher than remission （P〈0.01）. Conclusion： CRP as a chronic obstructive pul- monary disease acute exacerbation of sensitive and important index infection, and with AECOPD disease classification of serious degree a positive correlation.