原发性高血压患者血尿酸、血胱抑素C和肌酐值的观察

A Survey of Serum Uric Acid,Cystatin C and Creatinine Levels in Essential Hypertension

目的:观察原发性高血压(EH)患者血尿酸(UA)、血胱抑素C(Cys C)和肌酐(Cr)值,探讨其临床意义。方法:血尿酸和肌酐用酶法在全自动生化分析仪上测定,血胱抑素用比浊法在特定蛋白仪上测定。结果:200例EH患者伴发高尿酸血症(HUA)88例,其Cys C值(1.12±0.14)mg/L和Cr值(141.5±93.5)μmol/L明显高于非HUA者(P<0.05);随着年龄的增长和高血压分期的增加而明显升高,但Cr升高率明显后于Cys C的升高率和HUA的发生率(P<0.05)。结论:EH患者Cys C、Cr与HUA关系密切;UA、Cys C升高在Cr之前;UA是EH患者肾损害的早期表现。

Objective： To survey serum uric acid（UA）,cystatin C（Cys C） and creatinine（Cr） levels in patients with essential hypertension（EH）,and study its clinical significance.Methods： UA and Cr were measured by enzymatic method with automatic biochemistry analyzer,Cys C was measured by nephelometry with specific protein aparatus.Results： 88 cases were accompanied with hyperuricemia（HUA） in 200 patients with EH.Their mean Cys C value（1.12±0.14） mg/L and mean Cr value（141.5±93.5） μmol/L were higher than those in the patients without HUA significantly（P0.05）,and increased with the growth of age and stages of hypertension.However,the rising rate of Cr value was lower than Cys C and HUA incidence（P0.05）.Conclusion： Cys C and Cr values have close relation with HUA in patients with EH.UA and Cys C values rise before Cr value.UA is an early manifestation of impairment of renal function in patients with EH.