胃癌组织中表皮生长因子受体和环氧合酶-2的表达及其临床意义

Expression of epidermal growth factor receptor and cyclooxygenase-2 in gastric carcinoma tissues and their clinical significance

目的探讨表皮生长因子受体(epithelial growth factor receptor,EGFR)和环氧合酶-2(cyclooxygenase-2,COX-2)在胃癌组织中的表达及其临床意义与相互关系。方法采用免疫组化Envision二步法检测40例胃癌组织中EGFR和COX-2的表达。结果 IEGFR表达阳性率为72.50%(29/40),COX-2阳性表达率为52.50%(21/40),二者的表达与胃癌淋巴结转移明显相关(P<0.05);②EGFR和COX-2在胃癌中的阳性表达与临床分期有关,在TNM分期中Ⅲ+Ⅳ期阳性表达率高于Ⅰ+Ⅱ期(P<0.05);③胃癌组织中COX-2表达与EGFR表达之间存在相关性(P<0.05)。结论 COX-2和EGFR过度表达参与了胃癌的发生发展过程,并与其淋巴结转移和TNM分期有关;胃癌中COX-2和EGFR的表达具有正向协同性。

To investigate the expression of epidermal growth factor receptor（EGFR）and cyclooxygenase（COX）-2 in gastric carcinoma tissues and their clinical significance and correlation. The Envision immunohistochemical two-step method was used to detect the expression of EGFR and COX-2 in 40 cases of gastric carcinoma tissues. The positive expression rate of EGFR was 72.50%（29/40）,and that of COX-2 was 52.50%（21/40）.The expression of EGFR and COX-2 was significant correlated with lymph node metastasis in gastric carcinoma（P 0.05）.The positive expression of EGFR and COX-2 in gastric carcinoma was correlated with its clinical stage.The positive expression of EGFR and COX-2 in patients in stage Ⅲ＋Ⅳ was higher than that in stage I＋II（P 0.05）.The expression of EGFR was closely correlated with that of COX-2（P 0.05）. The overexpression of COX-2 and EGFR participates in the pathogenesis of gastric carcinoma,and is correlated with lymph node metastasis and the clinical stage of gastric carcinoma.Positive cooperativity can be seen in the expression of EGFR and COX-2 in gastric carcinoma.