成都市城乡结合部人群糖尿病大血管病变与超敏C反应蛋白及低密度脂蛋白胆固醇相关性的研究

Impact of diabetic macroangiopathy on correlation between high sensitivity C-reactive protein and low density lipoprotein cholesterol in urban fringe zone in Chengdu

目的探讨成都市城乡结合部糖尿病大血管病变患者超敏C-反应蛋白(hs-CRP)与低密度脂蛋白胆固醇(LDL-C)水平变化及其相互关系。方法分别检测40例无大血管并发症的2型糖尿病患者(无大血管并发症组)、40例合并大血管病变的2型糖尿病患者(大血管并发症组)及30例健康人(正常对照组)的血清hs-CRP、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、LDL-C浓度。结果 2型糖尿病患者无论有无大血管并发症,其hs-CRP、TC、TG、LDL-C水平均明显高于正常对照组(P<0.05);大血管并发症组hs-CRP、LDL-C水平均明显高于无大血管并发症组(P<0.05,P<0.01),且hs-CRP水平与LDL-C水平呈显著正相关(r=0.53,P<0.05),而HDL-c水平明显低于无大血管并发症组及正常对照组(P<0.05)。结论 hs-CRP及LDL-C可作为预测2型糖尿病并发大血管病变危险性的重要实验室指标,联合检测hs-CRP及LDL-C对预测及早期诊断治疗2型糖尿病并发大血管病变有重要的临床价值。

To investigate the impact of diabetic macroangiopathy on correlation between high sensitivity C-reactive protein（hs-CRP） and low density lipoprotein cholesterol（LDL-C） in urban fringe zone in Chengdu. Levels of hs-CRP,total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C） and LDL-C were detected in 40 type 2 diabetes patients with macroangiopathy,another 40 without macroangiopathy and 30 healthy controls. Levels of hs-CRP,TC,TG and LDL-C in controls were significantly higher those in patients with type 2 diabetes（P 0.05）,and those in patients with macroangiopathy were significantly higher than those in patients without macroangiopathy（P 0.05）.The hs-CRP level was positively correlated to the LDL-C level（r=0.53,P 0.05） in patients with macroangiopathy.The HDL-c level in patients with macroangiopathy was significantly lower than that in patients without macroangiopathy and the controls（P 0.05）. Hs-CRP and LDL-C can be used as the indicators for predicting the risk of macroangiopathy complicated by type 2 diabetes.The detection of them is benefit to the prediction and early diagnosis of type 2 diabetes with macroangiopathy.