摘要
抗凝血是抗血栓治疗的重要方法,在对抗凝治疗的处理中,很多药物治疗窗窄,需要进行血药浓度监测。目前研究开发的Xa因子直接抑制剂,作用直接,用药后无需监测,使用简便、安全,增加了抗凝治疗的可操作性。本文对Xa因子直接抑制剂利伐沙班、艾砒沙班、依杜沙班、奥米沙班的药理特性、临床应用研究等进行阐述。
Anticoagulation is an important method for the treatment of anticoagulant diseases,while many drugs have narrow therapeutic window and require monitoring of blood concentration. The new - developed factor Xa - directed anticoagulant has di- rect effect without monitoring after treatment and is convenient and safe to use,which increases the operability of anticoagulant therapy. This paper summarized the pharmacological properties and clinical application of factor Xa - directed anticoagulant such as rivaroxaban, apixaban, edoxaban and otamixaban.
出处
《齐鲁药事》
2012年第2期102-104,共3页
qilu pharmaceutical affairs
关键词
Xa因子直接抑制药
药理特性
临床研究
Factor Xa - directed anticoagulant
Pharmacological properties
Clinical research
