摘要
目的合成一种兼有香草醛活性和希夫碱功效的化合物,筛选具有镇静、抗癫疒间、抗癌的药物。方法用葡萄糖、香草醛为原料,经过乙酰化、溴代等步骤合成了中间体四乙酰葡萄糖香草醛苷,然后与对氯苯胺反应。结果合成了目标化合物Ⅳ。对目标化合物Ⅳ用IR、1HNMR、MS进行结构表征,分析证实所合成的化合物与预期结构一致。结论依据药物拼合原理,可以对香草醛进行结构改造和修饰,合成其希夫碱类化合物。
Objective To search for compounds of Schiff base which have both vanillin＇s bioactivity and Schiff bases, and filter sedative, antiepileptic and anticancer drugs. Methods Tetra-o-acetyl-α-D-vanillin-glucoside was synthesized by acetylation and bromination and other steps with glucose and vanillin, and it was reacted with chloraniline. Results Compound Ⅳ was obtained and the structure of it was identified by IR, 1 HNMR and MS. Conclusion Schiff base can be synthesized by structure reformation and modification for vanillin based on combination principle of medicine.
出处
《实用药物与临床》
CAS
2012年第2期88-90,共3页
Practical Pharmacy and Clinical Remedies
关键词
香草醛
希夫碱
衍生物
合成
Vanillin
Schiff base
Derivatives
Synthesize
