CCR5的表达在乳腺癌的诊断与转移中的临床价值

Expression and significance of chemokine receptor CCR5 for the diagnosis and metastasis of breast cancer

目的探讨趋化因子受体CCR5在乳腺癌组织及其腋窝转移淋巴结中的表达及意义。方法用免疫组织化学方法检测35例乳腺癌及其腋窝转移淋巴结组织、20例乳腺纤维腺瘤组织(对照组)中的CCR5。结果乳腺癌组织CCR5阳性率为74.2%(26/35),乳腺纤维腺瘤组织中未发现CCR5的表达,两种组织阳性表达率差异显著,P<0.01。腋窝淋巴结转移灶中,CCR5阳性者21例(60.0%,21/35),原发癌灶和腋窝淋巴节转移灶CCR5同时阳性者21例。结论 CCR5在乳腺癌组织及其腋窝淋巴结中有异常表达,其可能在乳腺癌的发生、发展及转移中发挥作用。

Objective Io explore the expression oi chemokme receptor t3t3Rb in breast cancer tissue and metastaUc aXlllary nodes, and its clinical significance. Methods CCR5 was detected by immunohistochemical staining in 35 cases of breast cancer specimens and metastatic axillary nodes and 20 cases of breast fibroadenoma specimens（normal control）. Results The positive rate of CCR5 in breast cancer tissue was 74.2% （26/35） ,higher than that in breast fibroadenoma （P^0.05）. The positive rate of CCR5 in metastatic axillary nodes was 60.0 % （21/35）, and there were 21 cases with positive expression of CCR5 in primary cancer tissue and metastatic axillary nodes simultaneously. Conclusion CCR5,which could be expressed abnormally in breast cancer tissues and metastatic axillary nodes,might play an important role in carcinogenesis,development and metastasis of breast cancer.