猴SⅠ区微刺激对SⅡ区伤害性神经元电活动的影响及与针刺的关系

INFLUENCE OF INTRACORTICAL MICROSTIMULATION OF SOMATOSENSORY AREA I UPON THE ELECTRICAL ACTIVITY OF THE NOCICEPTIVE NEURONS OF THE SOMATOSENSORY AREA Ⅱ IN MONKEY

在8只清醒、可活动猕猴进行了以下实验。用钨丝微电极在SⅡ区皮层进行了74次穿刺,从254个神经元中分离出61个对钾离子透入皮肤产生伤害性刺激起反应的神经元,其中兴奋型33个,抑制型28个。微电流刺激SⅠ区皮层时,SⅡ区的27个兴奋型神经元放电频率增加,24个抑制型神经元则表现为放电频率减少。15个痛敏神经元(兴奋型5个,抑制型10个)观察了针刺的效应。在针刺穴位时,13个伤害性神经元(4个兴奋型和9个抑制型)对伤害性刺激反应减弱。给予杜冷丁时,伤害性反应也被抑制。实验结果提示同侧SⅠ和SⅡ区在调制痛觉方面具有机能联系。

In order to study the functional relationship between the ipsila-teral SI area and the SⅡ area in modulating pain sensation, experiments wereperformed on 8 conscious, movable rhesus monkeys (Macaca Mulatta). 74penetrations in the S Ⅱ area were made by the tungsten microelectrode; and25S neurons were examined, 61 neurons which responded to noxious stimulationproduced by potassium iontophoresis in the skin of the leg were isolated andstudied. There were 33 excitatory neurons and 28 inhibitory neurons. Electri-cal discharges of 27 excitatory neurons were increased and electrical disch-arges of 24 inhibitory neurons were decreased during the stimulation of thecerebral cortex of the S Ⅰ area. The effect of aeupuncture was observed on 15neurons (5 excitatory, 10 inhibitory). The nociceptive response was inhibitedin 13 neurons (4excitatory, 9 inhibitory) during acupuncture. When Dolantinwas given, the nociceptive response was also inhibited. The experimentalresults showed that there are functional relationships between the ipsilateralS Ⅰ area and the S Ⅱ area in the modulation of the pain sensation.