高血压患者血清8-OHdG变化的研究

Study on 8-OHdG in patients with hypertension

目的探讨高血压病(essential hypertension,EH)患者血清8-羟基脱氧鸟苷酸(8-hydroxy-deoxyguanosine,8-OHdG)水平的变化。方法选择高血压患者40例,其中轻度高血压患者20例,中度高血压患者20例;健康对照组20例,应用酶联免疫吸附试验检测血清8-OHdG水平。结果轻度高血压患者与对照组相比,中度高血压患者与轻度高血压患者组比较血清8-OHdG浓度升高(P<0.01),而中度高血压患者与对照组比更高(P<0.01)。结论高血压患者存在8-OHdG水平的变化,且与高血压的病情严重程度相关;氧化应激及氧化损伤在中度高血压患者中更明显。

[ Objectives] To investigate the roles of serum 8-hydroxy-2＇-deoxyguanosine （8-OHdG） in patients with hypertension. [ Methods ] 40 patients with hypertension and 20 cases with mild hypertension and moderate hypertension were included randomly in this study, and 20 health subjects were included as control group. Serum 8-O- HdG levels of the patients from the 3 groups were measured. [ Results ] The serum levels of 8-OHdG were higher in patients with hypertension when compared with those in control group （P 〈0.01）. Moderate hypertension patients were much higher compared with mild hypertension （P 〈0.01）. [ Conclusions] Serum 8-OHdG in patients with hypertension would change significantly, and they might correlated with the severity of the disease. In the patients with moderate hypertension, the oxidative stress process would be much more significant.