颗粒酶系统在免疫编辑中的作用初探

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摘要在颗粒酶杀伤体系中,快速、高效的引发靶细胞死亡是由多个颗粒酶介导实现的.笔者就颗粒酶发挥作用的机制,探讨其在免疫编辑中的核心作用.细胞毒性T细胞（CTL）和自然杀伤（NK）细胞识别并杀死病毒感染或恶性转化细胞通过两个主要途径：①CTL使用其细胞表面的肿瘤坏死因子超家族（TNF）的配体结合靶细胞表达的相应受体使其死亡;②CTL / NK细胞还可以使用细胞毒颗粒胞外分泌途径,通过细胞介导的颗粒胞吐进入靶细胞,其中起重要作用的时膜裂解蛋白穿孔素,能促进颗粒酶发挥细胞毒作用,以快速,高效的促进细胞凋亡[1].

作者褚光李晓延

机构地区云南省昆明医学院云南省昆明市第一人民医院肝胆胰外科

出处《吉林医学》 CAS 2012年第5期1052-1054,共3页 Jilin Medical Journal

关键词颗粒酶凋亡肿瘤免疫编辑

分类号 R392.1 [医药卫生—免疫学]

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