常见侵袭性真菌疫苗的研究现状

Research Status of Common Invasive Fungal Vaccine

临床上存在抗肿瘤药物及抗生素滥用现象,使得条件致病性真菌感染疾病发病率升高,研究针对条件致病性真菌敏感的制剂-抗真菌药物及疫苗就显得十分重要。而临床应用抗真菌药物治疗的疗效不佳。出现较多耐药菌株,同时药物本身的毒副反应使患者无法耐受。因此,抗真菌治疗依然面临着严峻挑战。这无疑给研发真菌疫苗进行早期预防开辟了一条新的挑战途径。本文对真菌菌体疫苗、亚单位疫苗、DNA疫苗、树突状细胞与真菌疫苗以及含有失活基因的真菌疫苗进行综述。

Clinical antitumor antibiotics and drug abuse, increased incidence of opportunistic fungal infections, study of opportunistic fungal-sensitive preparation of antifungal drugs and vaccines are very important. Inefficacy of clinical application of antifungal drug therapy. More drug-resistant strains, and side effects of the drug itself so that patients could not be tolerated. Therefore, antifungal treatment is still faced with severe challenges. It has undoubtedly developed vaccine for early prevention of fungi has opened up a new and challenging way. This article on fungal cell vaccine and subunit vaccines, DNA vaccines, vaccine of dendritic cells and fungi as well as fungal vaccine containing the inactivation of genes for review.