平阳霉素联合地塞米松治疗成人睑缘部血管瘤临床分析

Curative effect of BleomycinA5 combined with dexamethasone local injection to treat adult palpebral-margin-haemangioma

目的 探讨平阳霉素联合地塞米松局部注射治疗成人睑缘部血管瘤临床疗效.方法 采用瘤体局部注射平阳霉素＋地塞米松治疗成人睑缘部血管瘤患者14例,男性6例,女性8例,观察注射后7d、1个月、3个月、6个月及12个月瘤体变化情况,评估临床疗效.结果 注射后第2天所有患者均出现注射部位肿胀,1～12个月随访观察,12例患者注射局部瘤体完全消失,皮肤未出现瘢痕及挛缩表现,2例患者注射后8个月局部瘤体复发,但较治疗前明显缩小.并予再次治疗后未再复发.结论 睑缘部血管瘤通过局部注射治疗可获得较满意的治疗效果,避免了手术治疗对睑缘部生理结构的破坏.

Objective To evaluate curative effect of the local injection of BleomycinA5 combined with dexamethasone to treat adult palpebral-margin-haemangioma. Methods Fourteen patients with palpebral-margin-haemangioma were treated by local injection of bleomycinA5 combined with dexamethasone,6 males and 8 females.The changing of the haemangioma body were observed 7days,1 month,3 months,6 months and 12 months after treatment,and the curative effect was evaluated. Results The 2nd day after treated,all patients＇ palpebras had uninfiammatory edema.Followed-up 1 month to 12 months,the haemangioma of 12 patients were disappeared,no recurrence.The palpebral margin＇s skin of all patients had no scar and contracture,2 patients were recurrence after 8 months,but smaller than before the first treatment,2 patients were treated by the same way,and no recurrence. Conclusions Using local injection of BleomycinA5 combined with dexamethasone to treat adult palpebral-margin-haemangioma have more satisfied clinical result,and can avoid destroy normal structure of palpebral margin treated by operation.