应用三维光学相干断层成像术测量正常人黄斑视网膜厚度

Normal macular thickness measurements in healthy eyes using three dimensional optical coherence Tomography

目的 利用三维光学相干断层成像术（3D optical coherence Tomography 3D-OCT）测量正常人黄斑区视网膜厚度,观察其与性别的相关性.方法 依据早期糖尿病视网膜病变研究组（Early Treatment Diabetic Retinopathy Study ETDRS）9分区,应用3D扫描测量226名6个年龄组正常人黄斑区视网膜厚度地形图并进行统计学分析.结果 正常人黄斑中心凹平均视网膜厚度为（220±14）μm,其中男性（225±13） μm与女性（214±12）μm的差异具有统计学意义（P＜0.05）.内环（1～3 mm直径区域即黄斑中心区）内鼻侧扇形区N1区平均视网膜厚度为（303±13） μm,上方扇形区S1区平均视网膜厚度为（300±11） μm,下方扇形区I1区平均视网膜厚度为（295±13） μm,颞侧扇形区T1区平均视网膜厚度为（289±12） μm.外环（3～6 mm直径区域内）鼻侧扇形区N2区平均视网膜厚度为（284±14） μm,上方扇形区S2区平均视网膜厚度为（267±12） μm,下方扇形区I2区平均视网膜厚度为（258±12） μm,颞侧扇形区T2区平均视网膜厚度为（257±11） μm.内环和外环男女差异均具有统计学意义（P＜0.05）.结论 正常人经3D-OCT测得的黄斑区视网膜厚度男女之间差异具有统计学意义,在分析黄斑视网膜厚度时应考虑性别差异.

Objective To demonstrate the macular thickness distribution in normal subjects by 3D-optical coherence Tomography and evaluate its association with gender. Methods Mean regional retinal thickness measurements on the Early Treatment Diabetic Retinopathy Study （ETDRS） layout were obtained by three-dimensional raster scanning in 226 normal eyes of subjects. Results Mean foveal thickness was 220 ± 14 μm; it was significantly greater in men （225 ±13 μm） than in women （214 ±12μm; P 〈0.05）.The thicknesses of inner ring in the nasal sector were 303±13μm,in the superior sector was 300±llμm,in the inferior sector was 295±13μm,in the temporal sector wan 289±12μm.The thicknesses of outer ring in the nasal sector were 284±14μm,in the superior sector was 267±12pm,in the inferior sector was 258±12μm,and in the temporal sector was 257±11μm.There was statistically significant in the men than in the women in all the quadrants of either the inner ring or the outer ring （P 〈0.05）. Conclusions There are significantly variables in the men than in the women in the three-dimensional macular thickness distribution in normal eyes.Macular thickness varies significantly with gender.These variables should be considered while evaluating macular thickness.