辅助性T细胞17和调节性T细胞与皮肤病

T helper 17 cells and regulatory T cells in skin diseases

辅助性T细胞17和调节性T细胞是近年发现的CD4＋T细胞亚群，辅助性T细胞17主要通过其分泌的白介素-17等细胞因子促进中性粒细胞的活化及募集，介导促炎症反应。调节性T细胞主要通过直接接触和分泌抑制性细胞因子等效应机制发挥免疫抑制作用，维持机体自身耐受。两者均参与自身免疫性疾病、感染性疾病及肿瘤等疾病的发生发展。有研究表明，辅助性T细胞17／调节性T细胞平衡异常引起全身或局部免疫应答异常是导致这些疾病的发生发展的重要机制之一。

T helper 17 （Thl7） cells and regulatory T （Treg） cells are a recently discovered CD4＋ T cell subset. Thl7 cells can promote the activation and recruitment of neutrophils, and mediate inflammation via secreting interleukin-17. Treg cells can suppress immune response and maintain immune tolerance mainly via direct contact and secretion of inhibitory cytokines. Both Thl7 and Treg cells participate in the initiation and progression of some autoimmune diseases, infectious diseases and tumors. Studies have shown that the abnormal immune response induced by the disequilibrium between Thl7 and Treg cells plays an important role in the pathogenesis of these diseases. The authors discuss the equilibrium between Thl7 and Treg cells in some skin diseases.