绵阳市中心医院2010年药品不良反应报告分析

Analysis on the ADR'S Reports in Mianyang Central Hospital in 2010

目的:了解我院药品不良反应(ADR)的发生特点,了解不良反应的发生情况和对患者的危害,分析不良反应产生的原因,促进临床用药合理、安全、有效。方法:采用描述性研究方法对我院587例ADR报告进行分类统计分析。结果:587例ADR中,女性多于男性,男女之比为0.98∶1;且超过50岁的老年患者有213例,占36.29%;单一用药581例,合并用药6例;以静脉给药方式为主;抗生素类药物引起的ADR占30.49%,其次为抗肿瘤药占11.41%;中药制剂占11.07%;皮肤及附件损害最多,占46.17%;ADR程度一般575例;因果关系评定为肯定21例,很可能502例,可能44例,可疑20例;治愈373例,好转214例。结论:应加强ADR的监测和ADR知识的宣传,避免或减少其重复发生。

Objective：To investigate the characteristics of adverse drug reactions （ADR） in our hospital so as to promote rational drug use in the clinic. Methods： The 587 ADR reports, which occurred in 2010,were analyzed by a descriptive research method. Resuits ： Among the 587 cases, female cases out numbered the male cases with the ratio of M： F = 0. 98 ： 1.00 ; 213 cases were elderly at the age of more than 50 years of age, which accounted for 36.29 % of the total; there were 581 single medication cases and six combined medication cases,chiefly through IV ; the antibiotic ADRs accounted for 30.49 % ; then Chinese raditional medicines at a percentage of 11.07 % ; skin and appendage impairment cases were the most with a percentage of 46. 17 % ; there were 575 moderate ca- ses; in the cause-effect relationship assessment, there were 21 certain cases,44 probable cases, and 20 possible cases; 373 patients were fully recovered,214 cases showed some improvement. Conclusion： To lessen or avoid the occurrence of ADRs, monitoring and publicizing of ADR knowledge should be emphasized.