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Hedgehog信号通路与胃疾病研究进展 被引量：4

Advances in research on relationship between Hedgehog signaling pathway and stomach diseases
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摘要 Hedgehog(Hh)信号通路是人类胚胎发育时的重要信号通路,在成熟个体,可能与维持胃部正常功能有关。研究显示Hh信号与H.pylori相关性胃炎、肠化及胃癌等疾病有关。本文就Hh信号通路与胃部疾病的关系的研究进展作一综述。 Hedgehog（Hh） signaling pathway,which plays a critical role in human embryonic development,may be important for homeostasis of the adult stomach.Researches reveal that Hh signal is related with H.pylori-associated gastritis,intestinal metaplasia and stomach cancer.This review focused on the progress of Hh in stomach diseases.
作者 黄利 彭琼 甘惠中
机构地区 安徽医科大学第三临床学院 合肥市第一人民医院消化内科
出处 《胃肠病学和肝病学杂志》 CAS 2012年第2期193-196,共4页 Chinese Journal of Gastroenterology and Hepatology
关键词 HEDGEHOG 信号通路 胃疾病 Hedgehog Signaling pathway Stomach disease
分类号 R573 [医药卫生—消化系统]
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参考文献31

  • 1Jia J,Kolterud A,Zeng H,et al.Suppressor of Fuscd inhibits mammalian Hedgehog signaling in the absence of cilia[J]. Dev Biol,2009,330(2):452-460.
  • 2Dierker T,Dreier R,Petersen A,et al.Heparan sulfate-modulated,metalloprotease-mediated sonic hedgehog release from producing cells[J].J Biol Chem,2009.284(12):8013-8022.
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  • 4Waghray M,Zavros Y,Saqui-Salces M,et al.Interleukin-1 beta promotes gastric atrophy through suppression of sonic hedgehog[J].Gastrotenterology,2010,138(2):562-572.
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胃肠病学和肝病学杂志
2012年 第2期

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